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The MRI Methods Research Group develops techniques for聽in vivo聽MRI, with a primary focus on characterization of anatomy and physiology, and聽quantitative mapping. The ability to use reproducible scanner-independent imaging markers enables new approaches in diagnostic imaging and patient follow-up after treatment. These quantitative imaging markers can be validated against more invasive reference measures, and provide volumetric non-invasive information.

This motivates our work in developing and validating such markers, and translating them for practical use in the clinical setting. Methods of interest include relaxation and magnetization transfer (MT), diffusion (DW-MRI), perfusion with dynamic contrast-enhanced (DCE-MRI) and magnetic susceptibility imaging and mapping. Currents applications include perfusion and diffusion in cancer, MT mapping in osteoarthritis, and myelin water mapping.

Our group also works with clinical medical physics to integrate聽practical MRI techniques in the radiation therapy (RT) process, including protocol optimization, image evaluation, and integration into planning. MRI provides non-invasive imaging of the human body with excellent soft tissue contrast, which is valuable for RT treatment planning and post-RT assessment.