In the world of medical imaging, PET research technicians play a pivotal role in advancing our understanding of the brain’s inner workings. At The Neuro, two dedicated research PET technologists,ÌýCatherine Saleh and Chris Hung-Hsin Hsiao, offer a glimpse into their daily routine, from calibrating cutting-edge equipment to working with new tracers. Through their work, they are part of groundbreaking research at the McConnell Brain Imaging Centre (BIC).
A PET scan reveals functional information about the body. It works by injecting a small amount of radioactive tracer into the body, which emits signals detected by the scanner to create detailed images of internal organs and tissues such as the brain. These images reveal metabolic and chemical activity, helping doctors and researchers understand, diagnose and monitor diseases like cancer, and brain disorders.
What does a typical day look like for PET research technicians at the McConnell Brain Imaging Centre (BIC)?
A typical day starts with calibrating the PET scan machine and coordinating with our radiochemistry team who produce all the required tracers on-site. We handle everything from tracer injections to running the scans and making sure participants are comfortable while they wait. Coordination with researchers is also essential to keep everything on schedule. In addition, we manage documentation, image reconstruction and data handling.
How do PET scans vary with each project or participant?
Each project’s requirements dictate the specifics of the technique. Some studies require a delayed scan after a small tracer dose, while others involve placing an IV catheter in the participant’s arm and infusing the tracer while scanning, others, for example, may require blood sampling and analysis, so we treat each case accordingly. ÌýThe choice of technique is often set well in advance based on the research’s needs.
How do you help participants feel comfortable, especially if they’re anxious about the procedure?
WeÌýstart by explaining everything well in advance, addressing concerns before participants even arrive. By working closely with research coordinators and their assistants, we try to provide a safe and welcoming space.
PET scans tend to be quite comfortable compared to other types of scans, as participants only need to remain still from the neck up, and we provide blankets or supports for the neck, head and knees for extra comfort. For those who prefer it and if the protocol allows for it, we can play music or a podcast during the scan, and there’s always a team member on standby. Participants who might be claustrophobic generally find our PET scanner less intimidating, as they’re only positioned up to the jaw and they can see their surroundings while in the scanner.
Do you adjust your approach for participants with specific needs, like those with cognitive impairments?
Yes, absolutely. For participants with cognitive impairments, we ensure someone is with them to provide assistance. For elderly participants, we add extra supports, blankets and knee pillows. Small adjustments like these help us meet participants' specific needs and ensure their comfort.
Can you explain some of the technology you use and how it contributes to research?
We work with high-resolution PET imaging, crucial for neuroscience research. The radiotracers we use aren’t typically available in hospitals yet, and they’re critical to our work. Our radiotracer library is one of the largest worldwide, allowing us to study neurodegenerative diseases, neurotransmitter pathways, and even epigenetic factors. Our radiochemists continuously develop new tracers to improve diagnostics, making them more accurate, easy to produce, and affordable.
The collaborative environment at the BIC drives innovation. Our team members and collaborators bring diverse perspectives from neurosciences, neurology, psychiatry, nuclear physics, epigenetics, psychology, computer science, and other fields, which spark creativity and enhance skills. Learning from colleagues across disciplines allows us all to grow scientifically and technically.
What do you find most rewarding about your work here?
We draw on a wide scientific base—neuroscience, programming, data analysis, and clinical trial work—to support the research. It’s rewarding to be part of discoveries that advance our understanding of conditions like Alzheimer's disease, dementia, traumatic brain injury, Parkinson’s, multiple sclerosis and substance use disorders. Breakthroughs in neurosciences can take time, but we see slow and steady new discoveries and knowing our work supports better diagnostic tools and treatments is incredibly fulfilling.
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