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The Feindel Brain and Mind Seminar Series will advance the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

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To watch via Vimeo, clickÌý

Véronique Bohbot

Full Professor, Department of Psychiatry, Douglas Hospital, ÎÛÎÛ²ÝÝ®ÊÓƵ University

´¡²ú²õ³Ù°ù²¹³¦³Ù:ÌýDifferent memory systems, dependent on separate parts of the brain, can sustain successful navigation. The hippocampus is implicated in spatial memory strategies used when finding one’s way in the environment, i.e. it is allocentric and involves remembering the relationship between landmarks. On the other hand, another strategy dependent on the caudate nucleus can also be used, i.e. the response strategy, which relies on making a series of stimulus-response associations (e.g. right and left turns from given positions that act as stimuli, such as turn right at the white building). Adults who use spatial memory strategies showed increased fMRI activity in the hippocampus, increased grey matter in the hippocampus, and better overall cognition compared to adults who use response strategies. Decades of research in my laboratory has shown that specific navigation strategies are associated with several genes, such as BDNF and ApoE, as well as hormones, such as cortisol and progesterone. Experiences dependent modulators such as age, habit, stress and rewards also modulate strategies dependent on the hippocampus and caudate nucleus. Moreover, certain technologies such as Global Position Systems (GPS) or video games inhibit the use of the hippocampus and are associated to poor spatial memory. These results have important implications on mental health because a larger hippocampus has been associated with healthy cognition in normal aging and with a reduced risk of numerous neurological and psychiatric disorders such as Alzheimer’s disease, Schizophrenia, Post-Traumatic Stress disorder and Depression.