Wayne Sossin, PhD
Wayne Sossin is interested in the specialized cellular and molecular events that shape brain function. Sossin 听is interested in neurodevelopmental disorders and the role that local protein synthesis in neurons plays in the origin and regulation of these disorders. 鈥疘n particular, the lab examines how neurons transport mRNAs to synapses as stalled ribosomes. Sossin has proposed that memories are stored using specialized synapses that can be distinguished by their molecular constituents. This proposal is being examined both in the simple nervous system of Aplysia, where behavioural memory is encoded by changes in the synaptic strength of identified neurons and in rodent models where powerful genetic tools allows for detailed correlations between molecular changes and behavior. 听
Anadolu M, Sun J, Li JT, Graber TE, Ortega J, Sossin WS. (2024) Puromycin reveals a distinct conformation of neuronal ribosomes (PNAS, Feb 13;121(7):e2306993121. doi: 10.1073/pnas.2306993121.听
听Zha C, Farah CA, Holt RJ, Ceroni F, AlAbdi L, Thuriot F, Khan AO, Helaby R, L茅vesque S, Alkuraya FS, Kraus A, Ragge N,鈥疭ossin WS.鈥�(2020)Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.鈥疕um. Mol. Genet.鈥�29: 3054-3063鈥��
Ferguson L, Hu J, Cai D, Chen S, Dunn TW, Pearce K, Glanzman DL, Schacher S, Sossin WS. (2019) J. Neuroscience Oct 30;39(44):8632-8644. doi: 10.1523/JNEUROSCI.0943-19.2019. Epub 2019 Sep 19.Sossin WS鈥痑nd Costa-Mattioli M (2018) Translational Control in the Brain in Health and Disease.鈥疌old Spring Harbor Perspectives in Biology鈥痙oi: 10.1101/cshperspect.a032912鈥�
Sossin WS鈥�(2018) Memory synapses are distinguished by distinct molecular complexes: A proposal.鈥疐rontiers in Synaptic Neuroscience鈥痙oi: 10.3389/fnsyn.2018.00005.鈥�
