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John White

John H. White, Ph.D.
Professor
Departments of Physiology and Medicine,
ÎÛÎÛ²ÝÝ®ÊÓƵ University
McIntyre Medical Sciences Building, Room 1128
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6
Office phone:(514) 398-8498
john.white [at] mcgill.ca

Research


Focus

There are three major projects in the laboratory.

(1) Molecular genetics of signaling by the nuclear vitamin D receptor and identification of vitamin D target genes implicated in (i) its capacity to stimulate innate immune responses, and (ii) its function as an anticancer agent.

(2) Chemical biology of vitamin D analogs. In collaboration with Dr. Jim Gleason in the Chemistry Department we are developing a series of bifunctional vitamin D analogs that combine agonism for the vitamin D receptor with inhibition of histone deacetylase activity.

(3) Characterization of novel factor identified in the lab called ligand-dependent corepressor (LCoR). LCoR was identified as a repressor of signaling by nuclear receptor transcription factors.

Keywords

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Selected Publications

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External Links

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