Professor John White has studied the mechanisms of vitamin D signalling and physiology for over 20 years. His laboratory investigates the molecular events underlying the roles of vitamin D in controlling cell proliferation and differentiation, and also discovered that the hormonal form of vitamin D is a direct inducer of antimicrobial innate immunity in humans.
The lab is composed of different teams working on various molecular genetics subjects (Immunity, Cancer, etc) with an special interest in hormonal vitamin D. The three main working teams are summarized below:
Regulation of innate immune responses to infection by vitamin D
manuella.bouttier [at] mail.mcgill.ca (Manuella Bouttier): Our goals are to understand the host macrophage response to Mycobacterium tuberculosis (M.tb.) infection through the use of cutting-edge genomics techniques, as mRNA and miRNA microarrays and ChIP sequencing. Continue Reading
mark.verway [at] mail.mcgill.ca (Mark Verway): Our previous studies have shown that M.tb. infection of macrophages induces a broad-ranging transcriptional response on the part of the host. Continue Reading
Babak Memari: M.tb. infection of macrophages leads to multiple signal transduction events, which alter the function of numerous transcription factors controlling the host transcriptional response to infection. Continue Reading
Molecular mechanisms underlying the cancer chemopreventive actions of vitamin D signaling
Reyhaneh Salehi Tabar: The laboratory has been interested for several years in the understanding the molecular events underlying the growing clinical evidence that vitamin D has cancer chemopreventive actions. Continue Reading
vassil.dimitrov [at] mail.mcgill.ca (听Vassil Dimitrov): Our goal is to analyze by ChIPseq the effect of vitamin D treatment on the binding of cMYC and MXD1 to DNA on a genome-wide scale. Continue Reading
fatemeh.fekrmandi [at] mail.mcgill.ca (Fatemeh Fekrmandi): Our main goals are to study the role of the VDR and FBW7 in controlling the proteasomal degradation of subunits of NF-kB. Continue Reading
Regulation of gene transcription by the corepressor LCoR
mario.calderon [at] mail.mcgill.ca (Mario R Caldero)mario.calderon [at] mail.mcgill.ca (n): The White laboratory identified LCoR (ligand-dependent corepressor) as a corepressor of ligand-bound nuclear receptors, a class of hormone-regulated transcription factors. Continue Reading
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