ÎÛÎÛ²ÝÝ®ÊÓƵ

To find a good match for the recipients, medical teams have so far focused on a particular set of genes called the human leukocyte antigen (HLA) complex. But scientists strongly suspect that there are many undiscovered genomic incompatibilities that underpin organ rejection.

Now, a large international team of transplant surgeons and scientists has come together to investigate the genetic factors behind transplant successes and failures. The project involves more than three dozen research institutions around the world, including the ÎÛÎÛ²ÝÝ®ÊÓƵ University and Génome Québec Innovation Centre, and is called the International Genetics & Translational Research in Transplantation Network (iGeneTRAiN).

Their efforts are detailed in a pair of papers published today in and in the journal (available online soon); co-authors of the Transplantation paper include Jiannis Ragoussis, ÎÛÎÛ²ÝÝ®ÊÓƵ University and Génome Québec Innovation Centre, and Chee L. Saw, from ÎÛÎÛ²ÝÝ®ÊÓƵ University Health Centre.

The consortium has grown rapidly in scale since its inception in 2012 and separate studies from its participating institutions around the globe – ongoing and completed – have already generated genomics and outcome data for over 32,000 organ donors and recipients.

The iGeneTRAiN projects are initially focused on kidney, liver, heart and lung transplant outcomes, with three ultimate goals:

• Discovering genetic variants that lead or contribute to rejection and other complications of transplantations;
• Finding new biomarkers in urine and blood samples that may predict rejection weeks or months before patients show symptoms;
• Individualizing patient treatments.

Ìý

More information on the project:

Articles:

• (available soon)

Ìý

Ìý